This video discusses the acetoacetic ester synthesis reaction mechanism to produced substituted ketone derivatives. This reaction begins with the removal of an alpha hydrogen by sodium ethoxide to produce a resonance stabilized carbanion intermediate. The second step is an SN2 reaction with an alkyl halide to add an R group followed by acid hydrolysis to convert the esters to a carboxylic acid. The last step involves decarboxylation or removal of the carboxylic acid functional group in the form of CO2.
Acetoacetic Ester Synthesis Reaction Mechanism - Substituted Ketones chemistry jobs
This video discusses the acetoacetic ester synthesis reaction mechanism to produced substituted ketone derivatives. This reaction begins with the removal of an alpha hydrogen by sodium ethoxide to produce a resonance stabilized carbanion intermediate. The second step is an SN2 reaction with an alkyl halide to add an R group followed by acid hydrolysis to convert the esters to a carboxylic acid. The last step involves decarboxylation or removal of the carboxylic acid functional group in the form of CO2.
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